A Growth-Fragmentation Approach for Modeling Microtubule Dynamic Instability
نویسندگان
چکیده
منابع مشابه
Microtubule dynamic instability
What are microtubules? One of three types of protein polymer that make up the cellular cytoskeleton, an elaborate array of filaments that are used to establish cell shape, facilitate cell motility, organize organelles and assist with cell division. Microtubules are stiff tubes, about 25 nm in diameter. During interphase, they serve as tracks on which organelles and the nucleus are positioned by...
متن کاملSelf-organized criticality and dynamic instability of microtubule growth.
We have shown that the distribution of lengths of site nucleated microtubules obey an algebraic power law relationship D(s) = A s(-tau), where D(s) is relative number of microtubules with length s, A and tau are constants. This relationship indicates the possibility of a self-organized criticality in the dynamic instability of microtubule growth.
متن کاملRegulation of microtubule dynamic instability.
Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differe...
متن کاملGeneration of microtubule stability subclasses by microtubule- associated proteins: implications for the microtubule "dynamic instability" model
We have developed a method to distinguish microtubule associated protein (MAP)-containing regions from MAP-free regions within a microtubule, or within microtubule sub-populations. In this method, we measure the MAP-dependent stabilization of microtubule regions to dilution-induced disassembly of the polymer. The appropriate microtubule regions are identified by assembly in the presence of [3H]...
متن کاملCompartment volume influences microtubule dynamic instability: a model study.
Microtubules (MTs) are cytoskeletal polymers that exhibit dynamic instability, the random alternation between growth and shrinkage. MT dynamic instability plays an essential role in cell development, division, and motility. To investigate dynamic instability, simulation models have been widely used. However, conditions under which the concentration of free tubulin fluctuates as a result of grow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2018
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-018-0531-2